Salivary a-synuclein and DJ-1: potential biomarkers for Parkinson’s disease
نویسندگان
چکیده
1 Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA 2 Department of Oral Biology, University of Washington School of Dentistry, Seattle, WA, USA 3 Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA 4 Department of Medicine (Dermatology), University of Washington School of Medicine, Seattle, WA, USA 5 Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 6 Department of Neuroscience and Behaviour, Ribeirão Preto School of Medicine, University of São Paulo, Brazil 7 Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA 8 Geriatric Research, Education, and Clinical Centre, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA 9 Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA 10 Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
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α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease
Parkinson's disease (PD) is the most common form of movement disorder and affects approximately 4% of the population aged over 80 years old. Currently, PD cannot be prevented or cured, and no single diagnostic biomarkers are available. Notably, recent studies suggest that two familial PD-linked molecules, α-synuclein and DJ-1, are present in cerebrospinal fluid (CSF) and that their levels may b...
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